Molecular design of upconversion nanoparticles for gene delivery,Chemical Science

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Molecular design of upconversion nanoparticles for gene delivery
Chemical Science ( IF 7.6 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1039/c7sc02956j
Wing-Fu Lai _{1,

2,

3,

4,

5} , Andrey L. Rogach _{6,

7,

8} , Wing-Tak Wong _{8,

9,

10}

Affiliation

Due to their large anti-Stokes shifts, sharp emission spectra and long excited-state lifetimes, upconversion nanoparticles (UCNPs) have attracted an increasing amount of research interests, and have shown great potential for enhancing the practical utility of gene therapy, whose versatility has been limited by existing gene delivery technologies that are basically mono-functional in nature. Despite this, up to now in-depth analysis of the development of UCNPs for gene delivery has been scant in the literature, even though there has been an upsurge of reviews on the chemistry of UCNPs and their applications in bioimaging and drug delivery. To fill this gap, this review aims to present the latest advances in the development and applications of UCNPs as gene carriers. Prior to describing the prominent works published in the field, a critical view on the properties, chemistry and molecular design of UCNPs for gene delivery is provided. With a synopsis of the recent advances in UCNP-mediated gene delivery, challenges and opportunities could be illuminated for clinical translation of works in this nascent field of research.

中文翻译：

用于基因传递的上转换纳米粒子的分子设计

由于其较大的反斯托克斯位移，清晰的发射光谱和长的激发态寿命，上转换纳米粒子（UCNPs）引起了越来越多的研究兴趣，并显示出增强基因治疗实用性的巨大潜力，其多功能性受到现有的基因传递技术的限制，这些技术本质上基本上是单功能的。尽管如此，迄今为止，尽管对UCNPs的化学及其在生物成像和药物递送中的应用的评论激增，但在文献中对用于基因递送的UCNPs的发展的深入分析仍很少。为了填补这一空白，本综述旨在介绍作为基因载体的UCNPs的开发和应用的最新进展。在描述该领域的著名作品之前，提供了有关基因传递的UCNPs的性质，化学和分子设计的批判性观点。概述了UCNP介导的基因递送的最新进展，可以为这一新兴研究领域的临床翻译提供挑战和机遇。

更新日期：2017-09-18

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