Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines,Advanced Synthesis & Catalysis

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Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-18 05:06:01 , DOI: 10.1002/adsc.201700669
Chunling Lan ₁ , Zhuang Tian ₁ , Xuchun Liang ₂ , Mingchun Gao ₁ , Wenting Liu ₁ , Yu An ₁ , Wencheng Fu ₂ , Guanming Jiao ₂ , Junjie Xiao ₂ , Bin Xu _{1,

3}

Affiliation

A novel method was developed for the construction of biologically active poly-substituted cinnolines from easily accessible hydrazones in good to excellent yields. A simple copper catalyst could efficiently promote C−N bond formation through selective C−H functionalization and dehydrogenative amination. Furthermore, the inert C−Heteroatom (O/F/N) bonds are susceptible to cleavage in high selectivity in the newly developed aerobic annulation, in preference to the alternative C−H bond, which is left intact.

中文翻译：

铜催化的Aero的有氧环化：直接获得辛诺啉

开发了一种新颖的方法，用于以易于获得的azo为原料，以良好或优异的产率构建具有生物活性的多取代cinnolines。一个简单的铜催化剂可以通过选择性的CH功能化和脱氢胺化有效地促进C N键的形成。此外，在新开发的好氧环化反应中，惰性C-杂原子（O / F / N）键易于以高选择性裂解，而不是保留完整的替代C-H键。

更新日期：2017-09-18

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