当前位置:
X-MOL 学术
›
Adv. Synth. Catal.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-18 05:06:01 , DOI: 10.1002/adsc.201700669 Chunling Lan 1 , Zhuang Tian 1 , Xuchun Liang 2 , Mingchun Gao 1 , Wenting Liu 1 , Yu An 1 , Wencheng Fu 2 , Guanming Jiao 2 , Junjie Xiao 2 , Bin Xu 1, 3
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-18 05:06:01 , DOI: 10.1002/adsc.201700669 Chunling Lan 1 , Zhuang Tian 1 , Xuchun Liang 2 , Mingchun Gao 1 , Wenting Liu 1 , Yu An 1 , Wencheng Fu 2 , Guanming Jiao 2 , Junjie Xiao 2 , Bin Xu 1, 3
Affiliation
A novel method was developed for the construction of biologically active poly-substituted cinnolines from easily accessible hydrazones in good to excellent yields. A simple copper catalyst could efficiently promote C−N bond formation through selective C−H functionalization and dehydrogenative amination. Furthermore, the inert C−Heteroatom (O/F/N) bonds are susceptible to cleavage in high selectivity in the newly developed aerobic annulation, in preference to the alternative C−H bond, which is left intact.
中文翻译:
铜催化的Aero的有氧环化:直接获得辛诺啉
开发了一种新颖的方法,用于以易于获得的azo为原料,以良好或优异的产率构建具有生物活性的多取代cinnolines。一个简单的铜催化剂可以通过选择性的CH功能化和脱氢胺化有效地促进C N键的形成。此外,在新开发的好氧环化反应中,惰性C-杂原子(O / F / N)键易于以高选择性裂解,而不是保留完整的替代C-H键。
更新日期:2017-09-18
中文翻译:
铜催化的Aero的有氧环化:直接获得辛诺啉
开发了一种新颖的方法,用于以易于获得的azo为原料,以良好或优异的产率构建具有生物活性的多取代cinnolines。一个简单的铜催化剂可以通过选择性的CH功能化和脱氢胺化有效地促进C N键的形成。此外,在新开发的好氧环化反应中,惰性C-杂原子(O / F / N)键易于以高选择性裂解,而不是保留完整的替代C-H键。