Desymmetrization of Cyclopentenediones via Organocatalytic Cross-Dehydrogenative Coupling,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Desymmetrization of Cyclopentenediones via Organocatalytic Cross-Dehydrogenative Coupling
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-18 01:55:50 , DOI: 10.1002/adsc.201700917
Fabrizio Vetica ₁ , Stephen Bailey ₁ , Pankaj Chauhan ₁ , Mathias Turberg ₁ , Adjmal Ghaur ₁ , Gerhard Raabe ₁ , Dieter Enders ₁

Affiliation

An enantioselective synthesis of cyclopentenediones bearing a pyrazole unit has been achieved through an organocatalytic Michael addition/oxidation process. This desymmetrization reaction led to the desired pyrazole-cyclopentenediones with high yield and good enantioselectivities. The postulated cross-dehydrogenative coupling-mechanism has been investigated via preliminary control experiments.

中文翻译：