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Size Controllable and Surface Tunable Zeolitic Imidazolate Framework-8–Poly(acrylic acid sodium salt) Nanocomposites for pH Responsive Drug Release and Enhanced in Vivo Cancer Treatment
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acsami.7b10064 Li Yan 1, 2 , Xianfeng Chen 3 , Zhigang Wang 4 , Xiujuan Zhang 5 , Xiaoyue Zhu 2 , Mengjiao Zhou 5 , Wei Chen 2 , Longbiao Huang 2 , Vellaisamy A. L. Roy 2 , Peter K. N. Yu 6 , Guangyu Zhu 4 , Wenjun Zhang 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acsami.7b10064 Li Yan 1, 2 , Xianfeng Chen 3 , Zhigang Wang 4 , Xiujuan Zhang 5 , Xiaoyue Zhu 2 , Mengjiao Zhou 5 , Wei Chen 2 , Longbiao Huang 2 , Vellaisamy A. L. Roy 2 , Peter K. N. Yu 6 , Guangyu Zhu 4 , Wenjun Zhang 2
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Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8–poly(acrylic acid sodium salt) (ZIF-8–PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8–PAAS nanocomposites have different sizes ranging from 30 to 200 nm and exhibit different crystallinity, and pH sensitivity. These nanocomposites can be employed as vectors to deliver doxorubicin for anticancer therapy, leading to greatly enhanced drug therapeutic efficacy when tested in cell lines and mice model. Systematic toxicity investigation including hematoxylin and eosin staining analysis of tumor and major organs, hematology analysis, and blood chemistry analysis indicates that the nanocomposites possess high biocompatibility. This work provides a strategy to make metal–organic frameworks (MOFs) nanocomposites with size tunability in nanoscale and flexible surface modification for various applications.
中文翻译：
尺寸可控制和表面可调的沸石咪唑盐骨架-8-聚（丙烯酸钠盐）纳米复合材料，用于pH敏感药物的释放和在体内癌症治疗中的增强
以PAAS纳米球为软模板，制备了纳米级尺寸可控和表面改性的沸石咪唑盐骨架8–聚丙烯酸钠盐（ZIF-8–PAAS）纳米复合材料。这些ZIF-8–PAAS纳米复合材料的尺寸在30到200 nm之间不等，并且具有不同的结晶度和pH敏感性。这些纳米复合材料可用作载体以递送阿霉素用于抗癌治疗，从而在细胞系和小鼠模型中进行测试时，大大提高了药物的治疗功效。系统毒性研究包括对肿瘤和主要器官的苏木精和曙红染色分析，血液学分析和血液化学分析，表明纳米复合材料具有很高的生物相容性。
更新日期：2017-09-18
中文翻译：
尺寸可控制和表面可调的沸石咪唑盐骨架-8-聚（丙烯酸钠盐）纳米复合材料，用于pH敏感药物的释放和在体内癌症治疗中的增强
以PAAS纳米球为软模板，制备了纳米级尺寸可控和表面改性的沸石咪唑盐骨架8–聚丙烯酸钠盐（ZIF-8–PAAS）纳米复合材料。这些ZIF-8–PAAS纳米复合材料的尺寸在30到200 nm之间不等，并且具有不同的结晶度和pH敏感性。这些纳米复合材料可用作载体以递送阿霉素用于抗癌治疗，从而在细胞系和小鼠模型中进行测试时，大大提高了药物的治疗功效。系统毒性研究包括对肿瘤和主要器官的苏木精和曙红染色分析，血液学分析和血液化学分析，表明纳米复合材料具有很高的生物相容性。
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