当前位置: X-MOL 学术ACS Appl. Mater. Interfaces › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Evaluation of the Photothermal Properties of a Reduced Graphene Oxide/Arginine Nanostructure for Near-Infrared Absorption
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acsami.7b11291
Mohadeseh Hashemi 1, 2, 3 , Meisam Omidi 4 , Bharadwaj Muralidharan 2, 5 , Hugh Smyth 3 , Mohammad A. Mohagheghi 6 , Javad Mohammadi 1 , Thomas E. Milner 2
Affiliation  

Strong near-infrared (NIR) absorption of reduced graphene oxide (rGO) make this material a candidate for photothermal therapy. The use of rGO has been limited by low stability in aqueous media due to the lack of surface hydrophilic groups. We report synthesis of a novel form of reduced graphene-arginine (rGO-Arg) as a nanoprobe. Introduction of Arg to the surface of rGO not only increases the stability in aqueous solutions but also increases cancer cell uptake. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) images are recorded to characterize the morphology of rGO-Arg. Fourier transform infrared (FTIR), X-ray photoelectron spectra (XPS), Raman, and UV–vis spectroscopy are utilized to analyze the physiochemical properties of rGO-Arg. Interaction of rGO-Arg with 808 nm laser light has been evaluated by measuring the absorption cross section in response to periodically modulated intensity to minimize artifacts arising from lateral thermal diffusion with a material scattering matched to a low scattering optical standard. Cell toxicity and cellular uptake by MD-MB-231 cell lines provide supporting data for the potential application of rGO-Arg for photothermal therapy. Absorption cross-section results suggest rGO-Arg is an excellent NIR absorber that is 3.2 times stronger in comparison to GO.

中文翻译:

氧化石墨烯/精氨酸还原纳米结构的近红外吸收光热性能的评估。

还原氧化石墨烯(rGO)的强近红外(NIR)吸收使其成为光热疗法的候选材料。由于缺少表面亲水基团,rGO的使用受到水性介质稳定性低的限制。我们报告合成的一种新型形式的还原石墨烯-精氨酸(rGO-Arg)作为纳米探针。将Arg引入rGO的表面不仅增加了水溶液的稳定性,而且还增加了癌细胞的摄取。记录原子力显微镜(AFM)和透射电子显微镜(TEM)图像以表征rGO-Arg的形态。傅里叶变换红外(FTIR),X射线光电子能谱(XPS),拉曼光谱和紫外可见光谱用于分析rGO-Arg的理化性质。rGO-Arg与808 nm激光的相互作用已通过测量吸收截面来进行评估,该吸收截面响应于周期性调制的强度,以最小化由横向热扩散引起的伪影,其材料散射与低散射光学标准相匹配。MD-MB-231细胞系的细胞毒性和细胞摄取为rGO-Arg在光热疗法中的潜在应用提供了支持性数据。吸收截面结果表明,rGO-Arg是一种出色的NIR吸收剂,是GO的3.2倍。MD-MB-231细胞系的细胞毒性和细胞摄取为rGO-Arg在光热疗法中的潜在应用提供了支持性数据。吸收截面结果表明,rGO-Arg是一种出色的NIR吸收剂,是GO的3.2倍。MD-MB-231细胞系的细胞毒性和细胞摄取为rGO-Arg在光热疗法中的潜在应用提供了支持性数据。吸收截面结果表明,rGO-Arg是一种出色的NIR吸收剂,是GO的3.2倍。
更新日期:2017-09-18
down
wechat
bug