Nanostructured Fibrous Membranes with Rose Spike-Like Architecture,Nano Letters

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Nanostructured Fibrous Membranes with Rose Spike-Like Architecture
Nano Letters ( IF 9.6 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.nanolett.7b02929
Amir Nasajpour _{1,

2} , Serena Mandla _{1,

2} , Sindu Shree ₃ , Ebrahim Mostafavi ₄ , Roholah Sharifi _{1,

2} , Akbar Khalilpour _{1,

2} , Saghi Saghazadeh _{1,

2} , Shabir Hassan _{1,

2} , Michael J. Mitchell _{5,

6} , Jeroen Leijten _{1,

2,

7} , Xu Hou ₈ , Alireza Moshaverinia ₉ , Nasim Annabi _{1,

2,

4} , Rainer Adelung ₃ , Yogendra Kumar Mishra ₃ , Su Ryon Shin _{10,

11} , Ali Tamayol _{10,

11,

12} , Ali Khademhosseini _{10,

11,

13}

Affiliation

Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, United States
Harvard−MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
Institute for Materials Science, Kiel University, Kaiserstraße 2, D-24143 Kiel, Germany
Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115-5000, United States
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Department of Chemical Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands
State Key Laboratory of Physical Chemistry of Solid Surface, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Weintraub Center for Reconstructive Biotechnology Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, California 90095, United States
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States
Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, The Republic of Korea
Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Nebraska 68588, United States
Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

中文翻译：

具有Rose Spike-Like架构的纳米结构纤维膜

纳米颗粒已经用于工程复合材料，以改善原始聚合物的内在性能和/或增加其功能性。大多数研究集中于在复合纤维内掺入球形纳米颗粒。在这里，我们将各向异性的支链状氧化锌（ZnO）纳米粒子结合到通过静电纺丝制造的纤维支架中。支链颗粒的添加导致它们从纤维中突出，模仿了玫瑰茎的结构。我们证明不同形状的颗粒的封装显着影响所得复合支架的理化和生物学活性。尤其是，支化的纳米颗粒引起聚合物基体的异质结晶，并提高了最终的机械应变和强度。而且，支化ZnO纳米颗粒的三维（3D）性质增强了复合支架对组织的粘附特性。另外，玫瑰茎样构建体提供了出色的抗菌活性，同时支持了真核细胞的生长。

更新日期：2017-09-18

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