Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis,Organic Letters

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Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1021/acs.orglett.7b02524
C. Henrique Alves Esteves ₁ , Christopher J. J. Hall ₁ , Peter D. Smith ₂ , Timothy J. Donohoe ₁

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A protected pyruvate equivalent is described that allows arylation and arylation/alkylation reactions to be performed at the methyl group. Utilization of the OBO derivative of the pyruvate ester allowed the application of palladium catalyzed arylation reactions together with subsequent alkylation, under basic conditions. Moreover, the OBO protecting group could be easily removed in one step to provide access to a wide range of substituted pyruvate derivatives.

中文翻译：

丙酮酸酚醛酸酯化和烷基化：OBO酯保护的丙酮酸酯作为有机合成中的有用试剂

描述了一种保护的丙酮酸酯当量，其允许在甲基上进行芳基化和芳基化/烷基化反应。丙酮酸酯的OBO衍生物的使用允许在碱性条件下进行钯催化的芳基化反应以及随后的烷基化。而且，可以很容易地在一个步骤中除去OBO保护基，以提供对广泛范围内取代的丙酮酸酯衍生物的接触。

更新日期：2017-09-18

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