Michael addition has been achieved with a variety of amino acid esters and 2- or 4-vinylpyridine. Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quinoxaline, benzoxazole, and quinolone. In reactions at a prochiral center, modest diastereoselectivities were observed with the formation of the new stereogenic carbon. NMR experiments indicate that the addition reaction is reversible under acidic conditions.

中文翻译：

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迈克尔加成涉及氨基酸酯与烯基N-杂环

用多种氨基酸酯和2-或4-乙烯基吡啶可实现迈克尔加成。用烯基取代的嘧啶，吡嗪，噻唑，喹喔啉，苯并恶唑和喹诺酮可以完成类似的反应。在前手性中心的反应中，观察到适度的非对映选择性，并形成了新的立体异构碳。NMR实验表明加成反应在酸性条件下是可逆的。