The phosphoinositide 3-kinase (PI3K) family is classified into three distinct classes (I, II and III). Class I is most relevant to cell growth and survival and has been the target for drug development of cancer. The class I PI3K pathway includes four isoforms: α, β, δ, and γ [1]. PI3Kδ and -γ expression is largely limited to leukocytes, while PI3K-α and -β are ubiquitously expressed [2]. PI3Kα mutations and amplifications have been identified across multiple cancer subtypes and both overexpression of PI3Kα and gain of function PI3Kα mutations were found to be oncogenic [3–6]. PI3Kα is also the primary isoform required for insulin signaling [7]. PI3Kβ isoform has roles in regulating formation and stability of integrin...

中文翻译：

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非霍奇金淋巴瘤中PI3K抑制剂的复兴

磷酸肌醇3-激酶（PI3K）家族分为三个不同的类别（I，II和III）。I类与细胞生长和存活最相关，并且已成为癌症药物开发的目标。I类PI3K途径包括四种同工型：α，β，δ和γ[1]。PI3Kδ和-γ的表达主要限于白细胞，而PI3K-α和-β则普遍存在[2]。已在多种癌症亚型中鉴定出PI3Kα突变和扩增，发现PI3Kα的过表达和功能性PI3Kα突变均具有致癌性[3-6]。PI3Kα也是胰岛素信号转导所需的主要同工型[7]。PI3Kβ同工型在调节整联蛋白的形成和稳定性中起作用。