The use of chemotherapy treatment is often limited by toxic side-effects caused to healthy cells. In general, most chemotherapy treatments cause DNA damage or stop cells in mitosis, targeting both dividing cancer and dividing healthy cells (e.g. gut epithelium, bone marrow, hair follicle). Clearly, DNA damaging chemotherapy treatments may cause damage to both cancer and healthy cells to generate toxic side-effects (Figure 1A). In a new study presented in this issue of Annals of Oncology, Mittra et al. challenge this concept and suggest that released cell-free chromatin (cfCh) may itself cause inflammation and DNA damage as a secondary event [1] (Figure 1B). The authors also demonstrate that treatment with DNAse I or the DNA-degrading agent Resveratrol-Cu may suppress some...

中文翻译：

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化学疗法诱导的毒性-DNA释放引起的次要作用？

化学疗法的使用通常受到对健康细胞造成的毒性副作用的限制。通常，大多数化学疗法会导致DNA损伤或有丝分裂中的终止细胞，靶向分裂中的癌症和分裂中的健康细胞（例如肠道上皮，骨髓，毛囊）。显然，DNA破坏性化学疗法可能会损害癌细胞和健康细胞，并产生毒性副作用（图1A）。在本期《肿瘤学年鉴》中提出的一项新研究中，Mittra等人。挑战这一概念，并提出释放的无细胞染色质（cfCh）本身可能会引起炎症和DNA损伤，这是继发事件[1]（图1B）。作者还证明了用DNAse I或DNA降解剂白藜芦醇-铜治疗可能会抑制某些...