Toxicity associated with chemotherapy is a major therapeutic challenge and is caused by chemotherapy-induced DNA damage and inflammation. We have recently reported that cell-free chromatin (cfCh) fragments released from dying cells can readily enter into healthy cells of the body to integrate into their genomes and induce DNA double-strand breaks, apoptosis and inflammation in them. We hypothesized that much of the toxicity of chemotherapy might be due to release of large quantities of cfCh from dying cells that could trigger an exaggerated DNA damage, apoptotic and inflammatory response in healthy cells over and above that caused by the drugs themselves.

中文翻译：

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通过中和或降解无细胞染色质的试剂预防化学疗法的毒性

与化学疗法相关的毒性是主要的治疗挑战，并且是由化学疗法引起的DNA损伤和炎症引起的。我们最近报道，从垂死的细胞中释放的无细胞染色质（cfCh）片段可以很容易地进入人体健康细胞，并整合到其基因组中，并在其中诱导DNA双链断裂，凋亡和炎症。我们假设化学疗法的许多毒性可能是由于垂死的细胞释放出大量的cfCh所致，可能导致健康细胞中过度的DNA损伤，凋亡和炎性反应，而不是药物本身所引起的。