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Clinical utility of circulating DNA analysis for rapid detection of actionable mutations to select metastatic colorectal patients for anti-EGFR treatment
Annals of Oncology ( IF 56.7 ) Pub Date : 2017-06-30 , DOI: 10.1093/annonc/mdx330
A.R. Thierry , S. El Messaoudi , C. Mollevi , J.L. Raoul , R. Guimbaud , D. Pezet , P. Artru , E. Assenat , C. Borg , M. Mathonnet , C. De La Fouchardière , O. Bouché , C. Gavoille , C. Fiess , B. Auzemery , R. Meddeb , E. Lopez-Crapez , C. Sanchez , B. Pastor , M. Ychou

While tumor-tissue remains the ‘gold standard’ for genetic analysis in cancer patients, it is challenged with the advent of circulating cell-free tumor DNA (ctDNA) analysis from blood samples. Here, we broaden our previous study on the clinical validation of plasma DNA in metastatic colorectal cancer patients, by evaluating its clinical utility under standard management care.

中文翻译:

循环DNA分析用于快速检测可操作突变以选择转移性结直肠癌患者进行抗EGFR治疗的临床实用性

尽管肿瘤组织仍然是癌症患者进行基因分析的“金标准”,但随着血液样本中循环无细胞肿瘤DNA(ctDNA)分析的出现,它受到了挑战。在这里,我们通过评估标准管理下的临床效用,扩大了我们先前对转移性结直肠癌患者血浆DNA的临床验证的研究。
更新日期:2017-09-18
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