Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study,European Heart Journal

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Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study
European Heart Journal ( IF 37.6 ) Pub Date : 2017-07-27 , DOI: 10.1093/eurheartj/ehx355
Denise Hilfiker-Kleiner ₁ , Arash Haghikia _{1,

2} , Dominik Berliner ₁ , Jens Vogel-Claussen ₃ , Johannes Schwab ₄ , Annegret Franke ₅ , Marziel Schwarzkopf ₅ , Philipp Ehlermann ₆ , Roman Pfister ₇ , Guido Michels ₇ , Ralf Westenfeld ₈ , Verena Stangl ₉ , Ingrid Kindermann ₁₀ , Uwe Kühl ₂ , Christiane E. Angermann ₁₁ , Axel Schlitt ₁₂ , Dieter Fischer ₁ , Edith Podewski ₁ , Michael Böhm ₁₀ , Karen Sliwa ₁₃ , Johann Bauersachs ₁

Affiliation

Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1. D-30625 Hannover, Germany
Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
Universitätsklinik für Innere Medizin 8 – Schwerpunkt Kardiologie und Institut für Radiologie und Neuroradiologie, Klinikum Nürnberg Süd, Paracelsus, Medizinische Privatuniversität Nürnberg, Breslauer Str. 201, 90471 Nürnberg, Germany
Faculty of Medicine, University Leipzig, Clinical Trial Centre (KKS), ZKS Leipzig, Haertelstr. 16-18, D-04103 Leipzig, Germany
Department of Cardiology, Angiology, and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Department of Cardiology, Pulmonology, and Vascular Medicine, University of Cologne, Cologne, Kerpenerstr. 62, 50937 Köln, Germany
Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany
Department for Cardiology and Angiology, Angiologie, Center for Cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Department of Internal Medicine III, University Hospital of the Saarland, 66421 Homburg/Saar, Germany
Department of Internal Medicine I, University Hospital Wuerzburg, Am Schwarzenberg 15, Haus A1597078 Würzburg, Germany
Department of Medicine III, Medizinische Fakultät der Martin Luther-Universität Halle-Wittenberg, Magdeburger Straβe 8, 06108 Halle, Germany
Faculty of Health Sciences, Hatter Institute of Cardiology Research in Africa, 2 Anzio Road, Chris Barnard Building, 4th Floor, OBSERVATORY 7925, South Africa

An anti-angiogenic cleaved prolactin fragment is considered causal for peripartum cardiomyopathy (PPCM). Experimental and first clinical observations suggested beneficial effects of the prolactin release inhibitor bromocriptine in PPCM.

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