Randomized controlled trials about the treatment of bouts of overt hepatic encephalopathy (OHE) are difficult to design and interpret, since bouts of OHE i) are relatively short episodes in which the dynamic of the response to treatment is relevant, ii) their occurrence and treatment is frequently linked to precipitating events. The study by Sidhu et al. in this issue of Hepatology is a model of proper design and provides evidence that L-ornithine-L-aspartate infusion for 5 days is an effective add on treatment to speed up recovery from bouts of OHE in comparison with a placebo treatment that does not contain amino acid nutrients. This article is protected by copyright. All rights reserved.

中文翻译：

---

解决关于 L-鸟氨酸 L-天冬氨酸明显 HE 的疑虑：谁以及如何治疗

关于明显肝性脑病 (OHE) 发作的治疗的随机对照试验难以设计和解释，因为 OHE 发作 i) 是相对较短的发作，其中对治疗的反应动态相关，ii) 它们的发生和治疗经常与突发事件有关。Sidhu 等人的研究。在本期《肝病学》中，提供了一个设计合理的模型，并提供证据表明，与不含有任何成分的安慰剂治疗相比，连续 5 天输注 L-鸟氨酸-L-天冬氨酸是一种有效的附加治疗，可加速 OHE 发作的恢复。氨基酸营养素。本文受版权保护。版权所有。