A practical synthesis and detailed development process of 2H-1,3-benzoxazine derivatives catalyzed by aldimine and trifluoromethanesulfonic acid is described. A broad range of substrates with diverse steric and electronic properties were explored. Aliphatic/aromatic/heteroaromatic substrates all proceed well under conditions which have been optimized into a robust, scalable process.

中文翻译：

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制备2 H -1,3-Benzoxazine衍生物的通用协议的开发

描述了一种实用的合成方法和详细的开发过程，该方法由亚胺和三氟甲磺酸催化合成2 H -1,3-苯并恶嗪衍生物。探索了具有不同空间和电子特性的各种基材。脂肪/芳族/杂芳族底物在已优化为强大，可扩展的工艺的条件下均能很好地进行。