Metal‐Free Ionic‐Liquid‐Mediated Synthesis of Benzimidazoles and Quinazolin‐4(3H)‐ones from Benzylamines,Asian Journal of Organic Chemistry

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Metal‐Free Ionic‐Liquid‐Mediated Synthesis of Benzimidazoles and Quinazolin‐4(3H)‐ones from Benzylamines
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-06-27 , DOI: 10.1002/ajoc.201700214
Rohit Sharma ₁ , Mohd. Abdullaha ₁ , Sandip B. Bharate ₁

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An expedient metal‐free synthetic protocol for the construction of benzimidazoles has been developed from o‐phenylenediamine and benzylamine, using an imidazolium‐based ionic liquid as the reaction medium. The reactions proceed by oxidation of benzylamine derivatives to their corresponding imines, followed by intramolecular cyclization, to yield benzimidazoles. Advantages of this method include: an environmentally friendly metal‐free process, recyclable reaction media, high yields, short reaction times, and the applicability for the synthesis of quinazolin‐4(3H)‐ones. An NMR spectroscopy study provided further insight into the reaction.

中文翻译：

无金属离子液体介导的苄胺合成苯并咪唑和喹唑啉-4（3H）-酮

使用基于咪唑鎓的离子液体作为反应介质，由邻苯二胺和苄胺开发了一种简便的无金属合成苯并咪唑的合成方案。反应通过将苄胺衍生物氧化成其相应的亚胺进行，然后进行分子内环化，得到苯并咪唑。该方法的优点包括：环保的无金属工艺，可循环使用的反应介质，高收率，较短的反应时间以及适用于合成喹唑啉-4（3 H）-酮。NMR光谱研究提供了对该反应的进一步了解。

更新日期：2017-06-27

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