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Stereoselective Synthesis of Anti‐Hepatitis B Drug, Entecavir, through Regio‐ and Stereoselective Epoxide Cleavage
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-02-24 , DOI: 10.1002/ajoc.201700032
Young Eum Hyun 1 , Hong-Rae Kim 1 , Yongseok Choi 2 , Lak Shin Jeong 1
Affiliation  

A stereoselective synthesis of entecavir, an anti‐hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII‐mediated regio‐ and stereoselective epoxide cleavage as key steps.

中文翻译:

通过区域和立体选择性环氧化物裂解,选择性合成抗乙型肝炎药物恩替卡韦

恩替卡韦是一种抗乙型肝炎(HBV)药物的立体选择性合成是通过区域选择性的异亚丙基裂解,立体选择性的Sharpless环氧化和Ti III介导的区域和立体选择性的环氧裂解来完成的。
更新日期:2017-02-24
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