Stereoselective Synthesis of Anti‐Hepatitis B Drug, Entecavir, through Regio‐ and Stereoselective Epoxide Cleavage,Asian Journal of Organic Chemistry

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Stereoselective Synthesis of Anti‐Hepatitis B Drug, Entecavir, through Regio‐ and Stereoselective Epoxide Cleavage
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-02-24 , DOI: 10.1002/ajoc.201700032
Young Eum Hyun ₁ , Hong-Rae Kim ₁ , Yongseok Choi ₂ , Lak Shin Jeong ₁

Affiliation

A stereoselective synthesis of entecavir, an anti‐hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and Ti^III‐mediated regio‐ and stereoselective epoxide cleavage as key steps.

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