Chemoselective and Enantioselective Hydrogenation of 2,4‐Diaryl‐3H‐benzo[b]azepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes,Asian Journal of Organic Chemistry

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Chemoselective and Enantioselective Hydrogenation of 2,4‐Diaryl‐3H‐benzo[b]azepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-04-13 , DOI: 10.1002/ajoc.201700094
Tingting Miao _{1,

2} , Baode Ma _{1,

2} , Ziyuan Ding _{1,

2} , Youran Liu _{1,

2} , Yan-Mei He _{1,

2} , Qing-Hua Fan _{1,

2}

Affiliation

An asymmetric hydrogenation of 2,4‐diaryl‐3H‐benzo[b]azepines, catalyzed by dendritic phosphinooxazoline (PHOX) iridium complexes, has been developed. Only the imine group was reduced, while the C=C bond remained untouched, affording a range of chiral 2,3‐dihydro‐1H‐benzo[b]azepine derivatives with good to excellent enantioselectivity (up to 91 % ee). A slightly positive dendritic effect on catalytic reactivity (up to 10 000 TON) was observed.

中文翻译：

树枝状膦酰基恶唑啉铱配合物催化的2,4-二芳基-3H-苯并[b]氮杂环庚烷的化学选择和对映选择加氢反应

已经开发了由树枝状膦基恶唑啉（PHOX）铱络合物催化的2,4-二芳基-3 H-苯并[ b ]氮杂烃的不对称氢化。仅亚胺基被还原，而C = C键保持不变，从而提供了一系列具有良好至优异对映选择性（高达91％ee）的手性2,3-二氢-1H-苯并[ b ] a庚因衍生物。观察到对催化反应性有轻微的积极树突作用（高达10000吨）。

更新日期：2017-04-13

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