Ratiometric Fluorescence Detection of Anthrax Biomarker with EuIII‐EDTA Functionalized Mixed Poly(diacetylene) Liposomes,Asian Journal of Organic Chemistry

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Ratiometric Fluorescence Detection of Anthrax Biomarker with EuIII‐EDTA Functionalized Mixed Poly(diacetylene) Liposomes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-05-03 , DOI: 10.1002/ajoc.201700158
Hyewon Seo ₁ , Subhankar Singha ₁ , Kyo Han Ahn ₁

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Anthrax, a bacteriogenic fatal infectious disease that is harmful to humans, requires the early and ready detection of its bacterial endospores. We report herein the use of poly(diacetylene acid) derived liposomes functionalized with Eu^III‐EDTA complexes as a ratiometric fluorescence detection system for dipicolinate, an anthrax biomarker and major component of the endospores. The red fluorescence of the polymerized liposomes provides a built‐in reference signal to monitor the relative change of the europium luminescence sensitized by the bound dipicolinate relative to the reference liposome emission. The liposome‐based integrated sensing system shows reasonable sensitivity as well as remarkable selectivity toward dipicolinate over other structurally related analytes. Paper strip sensors based on the polymerized liposomes are also prepared for the visible detection of dipicolinate.

中文翻译：

EuIII-EDTA功能化的混合聚（二乙炔）脂质体按比例荧光检测炭疽生物标志物

炭疽病是一种对人类有害的致细菌性致命传染病，需要及早发现其细菌内生孢子。我们在此报告了用Eu ^III官能化的聚（二乙炔酸）衍生脂质体的使用‐EDTA复合物可作为比率的荧光检测系统用于二吡啶甲酸酯，炭疽生物标记物和内生孢子的主要成分。聚合脂质体的红色荧光提供了一个内置的参考信号，以监控结合的吡啶二甲酸酯所致的发光相对于参考脂质体发射的相对变化。基于脂质体的集成传感系统显示出相对于其他结构相关分析物合理的灵敏度以及对二吡啶甲酸酯的显着选择性。还制备了基于聚合脂质体的纸条传感器，用于肉豆蔻酸酯的可见检测。

更新日期：2017-05-03

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