A Ru(II) NHC complex (loading down to 0.001 mol%) catalyzed cross coupling of a broad range of aromatic, aliphatic and heterocyclic alcohols is reported. This protocol also functioned efficiently under solvent‐free conditions. Remarkably, this catalytic system disclosed so far the highest TON of 288000 for the cross coupling of alcohols. Notably, this methodology was successfully applied for the one‐pot synthesis of a range of flavan derivatives. A detailed DFT studies and kinetic experiments were performed to understand the reaction mechanism as well as the high reactivity of this catalytic system.

中文翻译：

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醇的串联交叉偶联反应可持续合成β-烷基化仲醇和黄酮衍生物

据报道，Ru（II）NHC络合物（负载量低至0.001 mol％）催化了多种芳族，脂族和杂环醇的交叉偶联。该方案在无溶剂条件下也能有效发挥作用。显着地，该催化体系公开了迄今为止用于醇的交叉偶联的最高TON为288000。值得注意的是，该方法已成功应用于一系列黄烷衍生物的一锅法合成。进行了详细的DFT研究和动力学实验，以了解该催化体系的反应机理以及高反应活性。