Koch Institute for Integrative Cancer Research and Harvard-MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology; Cambridge MA 02139 USA
Department of Chemistry and Biochemistry; University of California at San Diego; La Jolla CA 92093 USA
Dipartimento di Scienze e Tecnologie Chimiche; University of Rome; Tor Vergata, Via della Ricerca Scientifica Rome 00133 Italy
Cancer Research Center; Sanford Burnham Prebys Medical Discovery Institute; La Jolla CA 92037 USA
Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science; Harvard-MIT Division of Health Sciences and Technology; Electrical Engineering and Computer Science; Massachusetts Institute of Technology; Cambridge MA 02139 USA
Howard Hughes Medical Institute; Massachusetts Institute of Technology; Cambridge MA 02139 USA
In article number 1701527, Sangeeta N. Bhatia and co‐workers engineer an antibacterial by fusing two peptide domains to target and kill bacteria and then encapsulate them in a biodegradable porous silicon nanoparticle. These nanomaterials kill bacteria and improve animal survival after treatment of a lung‐infection model. This approach represents a new strategy for the development of antibacterials to combat the rising incidence of antibiotic resistance in the clinic.
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