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Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment.
ACS Nano ( IF 15.8 ) Pub Date : 2017-09-15 , DOI: 10.1021/acsnano.7b04348 Yuqi Zhang 1, 2 , Qiongming Liu 3 , Jicheng Yu 1, 2 , Shuangjiang Yu 1, 4 , Jinqiang Wang 1 , Li Qiang 3 , Zhen Gu 1, 2, 5
ACS Nano ( IF 15.8 ) Pub Date : 2017-09-15 , DOI: 10.1021/acsnano.7b04348 Yuqi Zhang 1, 2 , Qiongming Liu 3 , Jicheng Yu 1, 2 , Shuangjiang Yu 1, 4 , Jinqiang Wang 1 , Li Qiang 3 , Zhen Gu 1, 2, 5
Affiliation
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Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation. This microneedle-based patch can effectively deliver browning agents to the subcutaneous adipocytes in a sustained manner and switch on the "browning" at the targeted region. It is demonstrated that this patch reduces treated fat pad size, increases whole body energy expenditure, and improves type-2 diabetes in vivo in a diet-induced obesity mouse model.
中文翻译：
用微针贴片局部诱导的脂肪组织褐变，用于肥胖症治疗。
肥胖是21世纪最严重的公共卫生问题之一，可能导致许多合并症，如2型糖尿病，心血管疾病和癌症。当前对肥胖的治疗包括饮食，体育锻炼，药物治疗以及外科手术，总是与低效或不希望的系统性副作用相关。为了提高治疗效率并减少副作用，我们开发了一种经皮褐变剂贴剂以局部诱导脂肪组织转化。这种基于微针的贴剂可以持续有效地将褐变剂递送至皮下脂肪细胞，并在目标区域开启“褐变”。事实证明，该贴剂可减少经处理的脂肪垫的尺寸，增加全身能量消耗，
更新日期：2017-09-15
中文翻译：
用微针贴片局部诱导的脂肪组织褐变，用于肥胖症治疗。
肥胖是21世纪最严重的公共卫生问题之一，可能导致许多合并症，如2型糖尿病，心血管疾病和癌症。当前对肥胖的治疗包括饮食，体育锻炼，药物治疗以及外科手术，总是与低效或不希望的系统性副作用相关。为了提高治疗效率并减少副作用，我们开发了一种经皮褐变剂贴剂以局部诱导脂肪组织转化。这种基于微针的贴剂可以持续有效地将褐变剂递送至皮下脂肪细胞，并在目标区域开启“褐变”。事实证明，该贴剂可减少经处理的脂肪垫的尺寸，增加全身能量消耗，
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