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Natural Products and Their Mimics as Targets of Opportunity for Discovery
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-09-15 00:00:00 , DOI: 10.1021/acs.joc.7b01368 Stephen F. Martin 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-09-15 00:00:00 , DOI: 10.1021/acs.joc.7b01368 Stephen F. Martin 1
Affiliation
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Diverse structural types of natural products and their mimics have served as targets of opportunity in our laboratory to inspire the discovery and development of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures. Furthermore, our efforts toward identifying novel compounds having useful biological properties led to the creation of new targets, many of which posed synthetic challenges that required the invention of new methodology. In this Perspective, selected examples of how we have exploited a diverse range of natural products and their mimics to create, explore, and solve a variety of problems in chemistry and biology will be discussed. The journey was not without its twists and turns, but the unexpected often led to new revelations and insights. Indeed, in our recent excursion into applications of synthetic organic chemistry to neuroscience, avoiding the more-traveled paths was richly rewarding.
中文翻译：
天然产物及其模仿物作为发现机会的目标
天然产物及其模拟物的不同结构类型已成为我们实验室中激发人们发现和开发组装多官能和多环分子结构的新方法和策略的机会的目标。此外，我们对鉴定具有有用生物学特性的新型化合物的努力导致了新靶标的产生，其中许多靶标提出了合成挑战，需要发明新方法。在此《观点》中，将讨论一些示例，这些示例说明了我们如何利用各种天然产物及其模拟物来创建，探索和解决化学和生物学方面的各种问题。旅程并非没有曲折，但意外的变化往往会带来新的启示和见解。确实，
更新日期：2017-09-15
中文翻译：
天然产物及其模仿物作为发现机会的目标
天然产物及其模拟物的不同结构类型已成为我们实验室中激发人们发现和开发组装多官能和多环分子结构的新方法和策略的机会的目标。此外，我们对鉴定具有有用生物学特性的新型化合物的努力导致了新靶标的产生，其中许多靶标提出了合成挑战，需要发明新方法。在此《观点》中，将讨论一些示例，这些示例说明了我们如何利用各种天然产物及其模拟物来创建，探索和解决化学和生物学方面的各种问题。旅程并非没有曲折，但意外的变化往往会带来新的启示和见解。确实，
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