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A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-09-14 , DOI: 10.1016/j.tetlet.2017.09.034
Daniel D. Sanz Sharley , Jonathan M.J. Williams

In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.



中文翻译:

基于Pd(OAc)2的体系催化的腈在水中的选择性水合

水中原位形成[Pd(OAc)2 bipy](bipy = 2,2'-bipyridyl)配合物在70°C时选择性催化多种有机腈的水合作用。在不存在水合促进添加剂如肟和羟胺的情况下,催化剂负载量为5 mol%可提供优异产率的伯酰胺产品。

更新日期:2017-09-14
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