Tumor metastasis is a multistep process that includes stimulation of angiogenesis, intravasation of tumor cells into blood or lymphatic vessels, and subsequent engraftment and extravasation to peripheral tissues where secondary tumors are seeded. It is known that metastatic progression is driven by mutational and epigenetic changes in tumor cells, but more recent efforts have focused on the evolving interplay between the tumor cell and the tumor microenvironment (TME) during invasion and transition from micrometastasis to macrometastasis. Whether the tumor cell or the subverted vascular niche/premetastatic niche is the driver of TME evolution remains the subject of debate. This webinar examines the role of tumor-secreted factors, including exosomes and tumor vascular niche—derived protumorigenic factors in tumor—environment interactions, and their implications for development of therapeutic interventions to arrest metastasis. View the Webinar

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网络研讨会 | 解读癌症：了解肿瘤侵袭和转移微环境

肿瘤转移是一个多步骤过程，包括刺激血管生成、肿瘤细胞内渗入血液或淋巴管，以及随后植入和外渗至继发性肿瘤播种的外周组织。众所周知，转移进展是由肿瘤细胞的突变和表观遗传变化驱动的，但最近的努力集中在肿瘤细胞和肿瘤微环境 (TME) 在侵袭和从微转移到大转移的转变过程中不断发展的相互作用。肿瘤细胞还是被破坏的血管生态位/转移前生态位是 TME 进化的驱动因素仍然是争论的主题。本次网络研讨会探讨了肿瘤分泌因子的作用，包括外泌体和肿瘤血管生态位——衍生的原肿瘤因子在肿瘤——环境相互作用中的作用，及其对开发治疗干预措施以阻止转移的影响。查看网络研讨会