Alginate is commonly used in the form of hydrogels in biomedical applications. It is known to be highly sensitive to liquid exposure and can degrade or solubilize easily. This study attempts to improve the mechanical and material properties in various humidity conditions and in liquid immersion of thin alginate films with the addition of unmodified and oxidized cellulose nanocrystals (CNCs, CNC-Ts). CNCs and CNC-Ts were added to alginate composites in varying amounts, and the material and mechanical properties were measured in dry, humid, and liquid conditions. It was shown that the properties can be enhanced with the addition of nanocellulose as tested by liquid uptake, and mechanical testing. These results suggest that the addition of TEMPO-oxidized nanocellulose crystals improves the performance and longevity of alginate when exposed to phosphate buffer solution (PBS) compared to deionized water. This improved performance was shown to have a limited effect on the adhesion of mesenchymal stem cells (MSCs) to the surface of the nanocomposites.

中文翻译：

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水化对纤维素纳米晶-海藻酸盐复合材料材料和力学性能的影响

藻酸盐通常以水凝胶的形式用于生物医学应用中。众所周知，它对液体暴露高度敏感，并且很容易降解或溶解。本研究试图通过添加未改性和氧化的纤维素纳米晶体（CNCs，CNC-Ts）来改善各种湿度条件下和液体浸没藻酸盐薄膜的机械和材料性能。将不同数量的 CNC 和 CNC-T 添加到藻酸盐复合材料中，并在干燥、潮湿和液体条件下测量材料和机械性能。结果表明，通过液体吸收和机械测试测试，添加纳米纤维素可以增强性能。这些结果表明，与去离子水相比，当暴露于磷酸盐缓冲溶液 (PBS) 时，添加 TEMPO 氧化的纳米纤维素晶体可提高藻酸盐的性能和寿命。这种改进的性能被证明对间充质干细胞 (MSCs) 与纳米复合材料表面的粘附作用有限。