Bagasse is a waste product of sugar extraction from sugar-cane with approximately 30% cellulose content. Cellulose was successfully extracted from sugar-cane bagasse using a modified mercerization-bleaching approach with a 40% yield. Extracted cellulose was converted to cellulose acetate for enhanced electrospinnability and blended with poly-l-Lactide or polydioxanone before solution electrospinning. Physico-chemical evaluation of the electrospun mats showed variable miscibility of blends. In vitro cell studies with L929 mouse fibroblast cells was quite conclusive as regards the biocompatibility of the blended mats with proliferative behavior of cells, extracellular matrix deposition and characteristic features of healthy cellular response. MTT assay indicated that the cellulose blended mats induced higher cell densities than the controls. Cellulose content influenced parameters such as fiber diameter, porosity and cell-matrix interaction of mats impacting on cell growth and behavior. Preliminary assessment of biomineralization potential of the mats by SEM showed nano-hydroxyapatite deposits on the electrospun fibers.

中文翻译：

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甘蔗渣衍生的纤维素增强了用于组织工程的聚丙交酯和聚二恶烷酮电纺支架的性能

蔗渣是从甘蔗中提取糖分的废品，纤维素含量约为30％。使用改良的丝光漂白法成功地从甘蔗渣中提取了纤维素，收率为40％。提取纤维素转化成醋酸纤维素增强electrospinnability并用聚共混升溶液静电纺丝之前丙交酯或聚二恶烷酮。电纺垫的理化评估显示，混合物具有不同的混溶性。体外关于L929小鼠成纤维细胞的细胞研究在混合垫的生物相容性，细胞的增殖行为，细胞外基质沉积和健康细胞反应的特征方面是非常有结论性的。MTT测定表明，纤维素共混垫比对照诱导更高的细胞密度。纤维素含量影响参数，例如纤维直径，孔隙率和席子的细胞-基质相互作用，从而影响细胞的生长和行为。通过SEM初步评估了垫子的生物矿化潜力，结果表明在电纺纤维上沉积了纳米羟基磷灰石。