Selective fluorescent probes enable unprecedented studies of metals, with sensitivity not only to identify the metal, but also to discern its oxidation state and coordination environment. Recent work has highlighted the potential of fluorescent probes for specific platinum species in understanding the activity of platinum anticancer agents. Here we report a rhodamine-based probe that selectively responds to aryl-bearing trans-platinum complexes, which represent an important class of potential anticancer agents. We subsequently demonstrate the utility of this probe for studying the rate of metabolism of these types of complexes.

中文翻译：

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用于研究活性跨铂类似物的代谢稳定性的荧光探针

选择性荧光探针使人们能够对金属进行前所未有的研究，其灵敏度不仅可以识别金属，还可以识别其氧化态和配位环境。最近的工作强调了荧光探针在了解铂类抗癌剂活性方面对特定铂族的潜力。在这里，我们报告了基于罗丹明的探针，该探针可选择性地响应含芳基的反铂复合物，这是一类重要的潜在抗癌剂。随后，我们证明了该探针在研究这些类型复合物的代谢速率方面的实用性。