Methylene C(sp3)–H Arylation of Aliphatic Ketones Using a Transient Directing Group,ACS Catalysis

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Methylene C(sp3)–H Arylation of Aliphatic Ketones Using a Transient Directing Group
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-09-14 00:00:00 , DOI: 10.1021/acscatal.7b02905
Kai Hong ₁ , Hojoon Park ₁ , Jin-Quan Yu ₁

Affiliation

Palladium-catalyzed methylene β-C(sp³)–H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp³)–H bond activation.

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