Tuberculous meningitis, a severe manifestation of extra-pulmonary tuberculosis,^1,2 has a mortality of more than 60% in HIV-infected people,³ with a 54% risk of chronic neurological complications in those who survive.² Rapid diagnosis and early initiation of treatment are needed to improve prognosis and minimise debilitating sequelae.² However, diagnosis is difficult, because cerebrospinal fluid typically contains few Mycobacterium tuberculosis bacilli and large sample volumes cannot always be obtained.

中文翻译：

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Xpert MTB / RIF Ultra：结核性脑膜炎的游戏规则改变者？

结核性脑膜炎是肺外结核的严重表现，^1,2的艾滋病毒感染者死亡率超过60％，³幸存者患有慢性神经系统并发症的风险为54％。^2需要快速诊断并尽早开始治疗，以改善预后并最大程度地减少使人衰弱的后遗症。²然而，由于脑脊液通常含有很少的结核分枝杆菌细菌，因此无法始终获得较大的样本量，因此诊断很困难。