The role of natural products in the drug development and discovery has been phenomenal. There has been an enormous interest in exploring all possible natural sources to identify structures exhibiting pronounced hypolipidemic activity albeit with no toxicity. The present review describes the profile of some interesting naturally occurring compounds and their derivatives as potential hypolipidemic agents. Some of the interesting natural chemotypes that can control the increased levels of plasma lipids and discussed in this review are compactin, lovastatin, gugglesterone, berberine, lupeol, phytol, polyprenol, aegeline, 4-hydroxyisoleucine, α-asarone, resveratrol, esculeoside A, swertiamarin, rutin, saucerneol B, curcumin and a clerodane diterpene.

天然产物在药物开发和发现中的作用非常显着。对探索所有可能的天然来源以鉴定具有明显降血脂活性的结构（尽管没有毒性）有着极大的兴趣。本综述描述了一些有趣的天然存在的化合物及其衍生物作为潜在的降血脂药的概况。可以控制血浆脂质水平增加并且在本综述中讨论的一些有趣的天然化学型包括紧密蛋白，洛伐他汀，古格列酮，小ber碱，羽扇豆醇，植醇，聚戊烯醇，爱琴茶碱，4-羟基异亮氨酸，α-细辛醚，白藜芦醇，七叶皂苷A， swertiamarin，芦丁，sauceneol B，姜黄素和clerodane diterpene。