Dynamic Changes in Material Properties and Degradation of Poly(ethylene glycol)–Hydrazone Gels as a Function of pH,Macromolecules

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Dynamic Changes in Material Properties and Degradation of Poly(ethylene glycol)–Hydrazone Gels as a Function of pH
Macromolecules ( IF 5.1 ) Pub Date : 2017-09-13 00:00:00 , DOI: 10.1021/acs.macromol.7b01246
Francisco Escobar ₁ , Kristi S. Anseth ₂ , Kelly M. Schultz ₁

Affiliation

Covalent adaptable hydrogels (CAHs) dynamically evolve when pushed out of equilibrium by force or change in environmental conditions. Adapting these materials for advanced biological applications, including 3D cell culture and drug delivery platforms, requires in-depth knowledge of the evolution of scaffold microstructure and rheological properties. We use multiple particle tracking microrheology to measure the changes in a poly(ethylene glycol)–hydrazone CAH structure and properties when pushed out of equilibrium by a single change in pH. We determine the CAH degrades rapidly at acidic pH with multiple cycles of almost complete degradation and gelation. At pH 7.1, the scaffold degrades and re-forms cross-links over approximately 1.5 weeks with small oscillations between degradation and gelation. These degradation cycles are well described with first- and second-order reaction kinetics. MPT is sensitive enough to measure the phase transitions in these materials giving new insight into how CAHs evolve and their potential uses in biological applications.

中文翻译：

材料特性的动态变化和聚乙二醇HH凝胶的降解与pH的关系

共价适应性水凝胶（CAHs）在受力或环境条件变化而无法平衡时会动态进化。要使这些材料适应包括3D细胞培养和药物递送平台在内的高级生物学应用，就需要深入了解支架微观结构和流变特性的发展。当通过单次改变pH值使其脱离平衡时，我们使用多个粒子跟踪微流变技术来测量聚乙二醇-– CAH结构和性质的变化。我们确定CAH在酸性pH值下会迅速降解，并具有几乎完全降解和胶凝的多个循环。在pH 7.1时，支架在约1.5周内降解并重新形成交联，降解和凝胶化之间的振荡很小。这些降解循环用一级和二级反应动力学很好地描述了。MPT足够灵敏，可以测量这些材料中的相变，从而使人们对CAHs的进化及其在生物应用中的潜在用途有了新的认识。

更新日期：2017-09-13

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