Catalytic One-Pot Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones,Organic Letters

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Catalytic One-Pot Synthesis of Trisubstituted Allenes from Terminal Alkynes and Ketones
Organic Letters ( IF 4.9 ) Pub Date : 2017-09-14 00:00:00 , DOI: 10.1021/acs.orglett.7b02443
Qi Liu _{1,

2} , Xinjun Tang ₁ , Yujuan Cai _{1,

2} , Shengming Ma _{1,

3}

Affiliation

An efficient one-pot synthesis of trisubstituted allenes from readily available terminal alkynes and ketones is realized. A wide range of trisubstituted allenes may be synthesized efficiently via this method. Preliminary mechanistic studies revealed that CuI and Ti(OEt)₄ are in charge of the formation of propargylic amine, while ZnBr₂ is responsible for the transformation from propargylic amine to allene.

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