An efficient enantioselective vinylogous aldol reaction of 3‐alkylidene oxindoles with α‐ketoesters by a bifunctional thiourea catalyst derived from cinchona alkaloid has been disclosed here. The simultaneous H‐bond directing dual activation of vinylogous nucleophile and electrophile afforded high yield (upto 92%) while obtaining excellent stereocontrol (upto 99% ee).

中文翻译：

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α-酮酸酯与3-亚烷基氧吲哚的不对称乙烯基醇醛反应

本文公开了一种由金鸡纳生物碱衍生的双官能硫脲催化剂，可实现3-亚烷基氧吲哚与α-酮酸酯的有效对映选择性乙烯基醇醛缩醛反应。乙烯亲核体和亲电体同时进行H键导向双活化可提供高收率（最高92％），同时获得出色的立体控制（最高99％ee）。