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Efficient Transformation of Alkyl 3‐nitro‐5‐(aryl/alkyl)isoxazole‐4‐carboxylates into 3‐amino‐ and 3‐hydrazinyl‐5‐aryl/alkyl‐isoxazole‐4‐carboxylates in Aqueous Solution
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-29 , DOI: 10.1002/adsc.201700881
Sushobhan Mukhopadhyay 1 , Dinesh S. Barak 1 , Ilesha Avasthi 2 , Sanjay Batra 1, 3
Affiliation  

An efficient protocol for transforming alkyl 3‐nitro‐5‐(aryl/alkyl)isoxazole‐4‐carboxylates into 3‐amino‐ and 3‐hydrazinyl‐5‐aryl/alkyl‐isoxazole‐4‐carboxylates is described. The reaction that is carried out in aqueous acetonitrile solution generally afford the products without any chromatographic purification. Investigations with the substrate scope reveal that this protocol is compatible only when the ester group is present at the C‐4 position of the isoxazole ring.

中文翻译:

在水溶液中将3-硝基-5-(芳基/烷基)异恶唑-4-羧酸烷基酯高效转化为3-氨基和3-肼基-5-芳基/烷基异恶唑-4-羧酸酯

描述了将烷基3-硝基-5-(芳基/烷基)异恶唑-4-羧酸酯转化为3-氨基和3-肼基-5-芳基/烷基异恶唑-4-羧酸酯的有效方案。在乙腈水溶液中进行的反应通常得到产物,无需任何色谱纯化。对底物范围的研究表明,该方案仅在异恶唑环的C-4位上存在酯基时才兼容。
更新日期:2017-09-29
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