当前位置：
X-MOL 学术
›
Eur. J. Org. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Thiophene-Based Organic D–π–A Dyes as Potent Sensitizers for Photodynamic Therapy
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-14 07:00:50 , DOI: 10.1002/ejoc.201701019 Shinichiro Fuse 1 , Miori Takizawa 1 , Keisuke Matsumura 1 , Shinichi Sato 1 , Shigetoshi Okazaki 2 , Hiroyuki Nakamura 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-14 07:00:50 , DOI: 10.1002/ejoc.201701019 Shinichiro Fuse 1 , Miori Takizawa 1 , Keisuke Matsumura 1 , Shinichi Sato 1 , Shigetoshi Okazaki 2 , Hiroyuki Nakamura 1
Affiliation
|
Readily accessible, thiophene-based organic D–π–A sensitizers exerted high phototoxicity. Structural requirements for phototoxicity were elucidated with the rapid synthesis of structurally simplified analogues and evaluation of their antitumor activity against HeLa cells under photoirradiation. Our sensitizers damaged cancer cells through both Type I and Type II mechanisms.
中文翻译：
噻吩基有机D–π–A染料作为光动力疗法的强敏剂
易于获得的基于噻吩的有机D–π–A敏化剂具有很高的光毒性。通过快速合成结构简化的类似物并评估其在光照射下对HeLa细胞的抗肿瘤活性，阐明了光毒性的结构要求。我们的敏化剂通过I型和II型机制破坏了癌细胞。
更新日期：2017-09-14
中文翻译：
噻吩基有机D–π–A染料作为光动力疗法的强敏剂
易于获得的基于噻吩的有机D–π–A敏化剂具有很高的光毒性。通过快速合成结构简化的类似物并评估其在光照射下对HeLa细胞的抗肿瘤活性，阐明了光毒性的结构要求。我们的敏化剂通过I型和II型机制破坏了癌细胞。
京公网安备 11010802027423号