Abstract Over the past several decades, the implementation of bioceramics in orthopedic bioengineering has become increasingly profound. The resemblance of the material to bone histomorphology makes them favorable to use in tissue engineering schemes, in addition to the evidence that they exhibit osteoconductivity and that many manifest the appropriate mechanical strength. Moreover, the strategy to use the 3D bioprinting technique holds the potential to consistently manufacture commercializable scaffolds, tailored for diverse clinical applications with physicochemical property-dependent biodegradation rates, and usher in a new era of effective hard tissue fabrication. This review is the first of its kind in that it has thoroughly compiled the most recent studies on 3D printing of bioceramic scaffolds to treat bone defects and anomalies. Manuscripts were mostly chosen from the last decade, highlighting the novelty of the approach to regenerative orthopedic bioengineering via ceramic-based 3DP technologies. Likewise, in addition to the materials perspective present in the body of this work, tissue engineering scaffold requirements were explained as well as the incorporation of drug delivery schemes for localized drug administration and cargo release rates in pre-clinical studies.

中文翻译：

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3D 打印生物陶瓷支架在骨科生物工程中的跨学科出现

摘要 几十年来，生物陶瓷在骨科生物工程中的应用日益深入。该材料与骨组织形态学的相似性使它们有利于在组织工程方案中使用，此外还有证据表明它们具有骨传导性并且许多表现出适当的机械强度。此外，使用 3D 生物打印技术的策略具有持续制造商业化支架的潜力，这些支架适用于具有物理化学性质依赖的生物降解率的各种临床应用，并开创了有效硬组织制造的新时代。这篇综述是同类综述中的第一篇，因为它彻底汇编了关于生物陶瓷支架的 3D 打印以治疗骨缺损和异常的最新研究。手稿大多选自过去十年，突出了通过基于陶瓷的 3DP 技术进行再生骨科生物工程方法的新颖性。同样，除了本工作正文中存在的材料观点外，还解释了组织工程支架的要求，以及在临床前研究中纳入局部给药和货物释放率的给药方案。