Desirable nanosystem that could not only deliver drugs safely and effectively into tumor sites, but also be expected to serve as photosensitizer to realize the photodynamic therapeutic function, would be of great significance in the synergistic cancer therapy. To perform this task, a multifunctional nanosystem has been developed for markedly enhanced cancer therapeutic efficacy by loading chemotherapy agent (doxorubicin hydrochloride, DOX) and photosensitive drug chlorin e6 (Ce6) into the channels of mesoporous zirconium dioxide (ZrO₂) layer which coats on Nd³⁺-doped upconversion nanoparticles (UCNPs). As a temperature sensitive phase change material (PCM), the loaded tetradecanol was served as switch for control release of DOX and reactive oxygen species (ROS) in the condition of enhanced temperature triggered by the near infrared (NIR) light irradiation. The hyperthermia generated from the UCNPs cores exposed to NIR laser could raise the temperature of tumor location to 47.8 °C. The as-synthesized UCNPs@ZrO₂-Ce6/DOX/PCM nanosystem demonstrates an excellent in vivo synergistic effect by administrating into U14 tumor-bearing mice via intravenous injection, under mild NIR laser irradiation (0.5 W cm⁻², 5 min break after 5 min irradiation). In a word, our experimental results indicate that the finely designed UCNPs@ZrO₂-Ce6/DOX/PCM may act as an ideal nanoplatform for multiple imaging guided tumor therapy.

中文翻译：

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多功能介孔ZrO ₂包封的上转换纳米粒子用于轻度近红外光激活的协同癌症治疗

期望的纳米系统不仅可以安全有效地将药物递送到肿瘤部位，而且有望用作实现光动力治疗功能的光敏剂，在协同癌症治疗中将具有重要意义。为了执行此任务，已经开发了一种多功能纳米系统，通过将化学治疗剂（盐酸阿霉素，DOX）和光敏药物二氢卟酚e6（Ce6）加载到中孔二氧化锆（ZrO ₂）层的通道中，从而显着增强了癌症的治疗效果。钕³⁺掺杂的上转换纳米粒子（UCNPs）。作为对温度敏感的相变材料（PCM），在由近红外（NIR）光辐照引发的温度升高的条件下，负载的十四烷可用作控制DOX和活性氧物质（ROS）释放的开关。从暴露在近红外激光下的UCNPs核产生的高温会使肿瘤部位的温度升高到47.8°C。所合成的UCNPs @的ZrO ₂ -Ce6 / DOX / PCM纳米系统演示了一个极好的体内通过施用进入U14荷瘤小鼠的协同作用通过静脉内注射，轻度NIR激光照射（0.5W厘米下^-2，照射5分钟后中断5分钟）。总之，我们的实验结果表明，精心设计的UCNPs @ ZrO ₂ -Ce6 / DOX / PCM可以作为理想的纳米平台，用于多种影像引导的肿瘤治疗。