The construction and evaluation of a Cyclic Olefin Copolymer (COC)-based continuous flow potentiometric microanalyzer to simultaneously monitor potassium, chloride and nitrate ions in samples from an on-board water recycling process expected to be installed in future manned space missions is presented. The main goals accomplished in this work address the specific required characteristics for a miniaturized on-line monitoring system to control water quality in such missions. To begin with, the integration of three ion-selective electrodes (ISEs) and a reference electrode in a compact microfluidic platform that incorporates a simple automatic autocalibration process allows obtaining information about the concentration of the three ions with optimal analytical response characteristics, but moreover with low reagents consumption and therefore with few waste generation, which is critical for this specific application. By a simple signal processing (signal removal) the chloride ion interference on the nitrate electrode response can be eliminated. Furthermore, all fluidics management is performed by computer-controlled microvalves and micropumps, so no manual intervention of the crew is necessary. The analytical features provided by the microsystem after the optimization process were a linear range from 6.3 to 630 mg L-1 and a detection limit of 0.51 mg L-1 for the potassium electrode, a linear range from 10 to 1000 mg L-1 and a detection limit of 1.58 mg L-1 for the chloride electrode and a linear range from 10 to 1000 mg L-1 and a detection limit of 3.37 mg L-1 for the nitrate electrode with a reproducibility (RSD) of 4%, 2% and 3% respectively. Sample throughput was 12 h-1 with a reagent consumptions lower than 2 mL per analysis.

中文翻译：

---

用于未来载人航天任务的多参数聚合物电位分析微系统

介绍了基于环烯烃共聚物 (COC) 的连续流动电位微量分析仪的构建和评估，以同时监测来自预计将安装在未来载人航天任务中的机载水回收过程样品中的钾离子、氯离子和硝酸根离子。在这项工作中完成的主要目标解决了在此类任务中控制水质的小型化在线监测系统所需的特定特性。首先，将三个离子选择电极 (ISE) 和一个参考电极集成到一个紧凑的微流体平台中，该平台结合了一个简单的自动自动校准过程，可以获得有关具有最佳分析响应特性的三个离子浓度的信息，但此外，试剂消耗低，因此产生的废物很少，这对于该特定应用至关重要。通过简单的信号处理（信号去除），可以消除氯离子对硝酸盐电极响应的干扰。此外，所有流体管理均由计算机控制的微型阀和微型泵执行，因此无需船员手动干预。优化过程后微系统提供的分析特征是钾电极的线性范围为 6.3 至 630 mg L-1，检测限为 0.51 mg L-1，线性范围为 10 至 1000 mg L-1 和氯化物电极的检出限为 1.58 mg L-1，线性范围为 10 至 1000 mg L-1，硝酸盐电极的检出限为 3.37 mg L-1，重现性 (RSD) 为 4%，分别为 2% 和 3%。样品通量为 12 h-1，每次分析的试剂消耗量低于 2 mL。