That intense demand for both high sensitivity and high reliability has been a key factor strengthening the surface enhanced Raman spectroscopy (SERS) in the analytical application, particular in the hyphenation with pre-concentration technique. Credible data acquisition and processing is very dependent on the stable and uniform performance of SERS-active substrate. Here, a reliable and uniform ultrathin-layer Au was proposed for protecting the porous Ag fiber (porous Ag@Au) and applied in the solid phase microextraction coupled with SERS. The Au layer was carefully deposited on porous Ag surface to form the uniform film by a galvanic-free displacement reaction. This coating endowed the substrate with high oxidation-resistance under heating and good durability in the atmosphere condition. The extraction and SERS performance of Nitrofurazone and Semicarbazide were investigated on this fiber, the bands at 1350 cm-1 and 1387 cm-1 were selected as the characteristic peaks for quantitative determination, respectively. This robust and sensitive substrate provide the high enhancement factor of 1.3 × 106 and low LOD of 5.1 ppb for the extraction and identification of Nitrofurazone compounds. Importantly, this work develops a versatile strategy for rapid detection of prohibited antibiotic and its marker residue in a complex matrix.

中文翻译：

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高可靠和坚固的超薄层金涂层多孔银基材通过无电沉积进行固相微萃取结合表面增强拉曼光谱

对高灵敏度和高可靠性的强烈需求一直是在分析应用中加强表面增强拉曼光谱 (SERS) 的关键因素，特别是在预浓缩技术的连字符中。可靠的数据采集和处理非常依赖于 SERS 活性基底的稳定和统一的性能。在这里，提出了一种可靠且均匀的超薄层 Au 来保护多孔 Ag 纤维（多孔 Ag@Au），并将其应用于与 SERS 结合的固相微萃取。Au层小心地沉积在多孔Ag表面上，通过无电流置换反应形成均匀的薄膜。该涂层赋予基材在加热下具有高抗氧化性和在大气条件下良好的耐久性。对该纤维进行了呋喃西林和氨基脲的萃取和SERS性能研究，分别选取1350 cm-1和1387 cm-1处的谱带作为特征峰进行定量。这种坚固而灵敏的底物提供了 1.3 × 106 的高增强因子和 5.1 ppb 的低 LOD，用于提取和鉴定呋喃西林化合物。重要的是，这项工作开发了一种通用策略，用于快速检测复杂基质中的禁用抗生素及其标记物残留。1 ppb 用于硝基呋喃酮化合物的提取和鉴定。重要的是，这项工作开发了一种通用策略，用于快速检测复杂基质中的禁用抗生素及其标记物残留。1 ppb 用于硝基呋喃酮化合物的提取和鉴定。重要的是，这项工作开发了一种通用策略，用于快速检测复杂基质中的禁用抗生素及其标记物残留。