Surface-induced nucleation of carbamazepine (CBZ) in ethanol was investigated with different surface materials; glass, polytetrafluoroethylene (PTFE) and tin. The introduction of foreign surfaces with different areas and surface chemistry into the solution had an impact on the crystal morphology and polymorphic form (Form II or III). With increase in supersaturation, a higher possibility of crystallisation of CBZ metastable Form II was observed, as expected. Increasing the number of inserts resulted in a direct increase in the surface area available for heterogeneous nucleation. The increase in surface area resulted in the greater possibility of obtaining the metastable Form II of CBZ. The stable Form III preferred to nucleate on tin than on glass and PTFE. The results indicate the two different polymorph of CBZ can be selectively crystalliesd out from solution with the aid of a foreign surface. The kinetics mechanism of heterogeneous nucleation of different polymorphs induced by foreign surfaces were discussed. The potential applications will be used to control and design the crystallisation process.

中文翻译：

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卡马西平多晶型物在不同表面性质上的选择性结晶

用不同的表面材料研究了卡马西平（CBZ）在乙醇中的表面诱导成核作用。玻璃，聚四氟乙烯（PTFE）和锡。将具有不同面积和表面化学性质的异物表面引入溶液中会影响晶体形态和多晶型形式（晶型II或III）。随着过饱和度的增加，可以预料到CBZ亚稳晶型II结晶的可能性更高。插入物数量的增加导致可用于异相成核的表面积的直接增加。表面积的增加导致获得亚稳CBZ形式II的更大可能性。稳定的晶型III在玻璃上比在玻璃和PTFE上更易于成核。结果表明，可以借助异物表面从溶液中选择性地结晶出两种不同的CBZ多晶型物。讨论了异质表面诱导的不同多晶型异质成核的动力学机理。潜在的应用将用于控制和设计结晶过程。