Prostate cancer: BET inhibitors — SPOP right there!

Nature Reviews Cancer, Published online: 8 September 2017; doi:10.1038/nrc.2017.80

Although speckle-type POZ protein (SPOP) is the most frequently mutated gene in primary prostate cancer, its therapeutic implications are incompletely understood. Now, three studies describe mechanisms of resistance to bromodomain and extraterminal (BET) protein inhibitors in SPOP-mutated prostate cancer.

中文翻译：

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前列腺癌：BET抑制剂-SPOP就在那！

前列腺癌：BET抑制剂-SPOP就在那！

Nature Reviews Cancer，在线发表：2017年9月8日; doi：10.1038 / nrc.2017.80

尽管斑点型POZ蛋白（SPOP）是原发性前列腺癌中最常见的突变基因，但其治疗意义尚不完全清楚。现在，三项研究描述了在SPOP突变的前列腺癌中对溴结构域和末端外（BET）蛋白抑制剂的耐药机制。