The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

中文翻译：

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4D核组计划

4D Nucleome Network 旨在开发和应用方法来绘制人类和小鼠基因组在空间和时间上的结构和动力学，以期更深入地了解细胞核的组织和功能机制。该项目将开发和基准测量基因组构象和核组织的实验和计算方法，并研究这些方法如何促进基因调控和其他基因组功能。经过验证的实验技术将与生物物理学方法相结合，以生成不同生物状态下的空间基因组组织的定量模型，包括细胞群和单细胞。