Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation. (Funded by the French Ministry of Health; CLOSE ClinicalTrials.gov number, NCT00562289.)

中文翻译：

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中风后闭孔卵圆形闭塞或抗凝与抗血小板

在近期因PFO伴发房间隔动脉瘤或房间隔大的原因而发生隐源性卒中的患者中，PFO封闭联合抗血小板治疗的患者中风复发率低于单独抗血小板治疗的患者。PFO封堵与房颤风险增加有关。（由法国卫生部资助； CLOSE ClinicalTrials.gov编号，NCT00562289。）