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Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke
The New England Journal of Medicine ( IF 96.2 ) Pub Date : 2017-09-13 , DOI: 10.1056/nejmoa1705915
Jean-Louis Mas , Geneviève Derumeaux , Benoît Guillon , Evelyne Massardier , Hassan Hosseini , Laura Mechtouff , Caroline Arquizan , Yannick Béjot , Fabrice Vuillier , Olivier Detante , Céline Guidoux , Sandrine Canaple , Claudia Vaduva , Nelly Dequatre-Ponchelle , Igor Sibon , Pierre Garnier , Anna Ferrier , Serge Timsit , Emmanuelle Robinet-Borgomano , Denis Sablot , Jean-Christophe Lacour , Mathieu Zuber , Pascal Favrole , Jean-François Pinel , Marion Apoil , Peggy Reiner , Catherine Lefebvre , Patrice Guérin , Christophe Piot , Roland Rossi , Jean-Luc Dubois-Randé , Jean-Christophe Eicher , Nicolas Meneveau , Jean-René Lusson , Bernard Bertrand , Jean-Marc Schleich , François Godart , Jean-Benoit Thambo , Laurent Leborgne , Patrik Michel , Luc Pierard , Guillaume Turc , Martine Barthelet , Anaïs Charles-Nelson , Christian Weimar , Thierry Moulin , Jean-Michel Juliard , Gilles Chatellier

Among patients who had had a recent cryptogenic stroke attributed to PFO with an associated atrial septal aneurysm or large interatrial shunt, the rate of stroke recurrence was lower among those assigned to PFO closure combined with antiplatelet therapy than among those assigned to antiplatelet therapy alone. PFO closure was associated with an increased risk of atrial fibrillation. (Funded by the French Ministry of Health; CLOSE ClinicalTrials.gov number, NCT00562289.)

中文翻译:

中风后闭孔卵圆形闭塞或抗凝与抗血小板

在近期因PFO伴发房间隔动脉瘤或房间隔大的原因而发生隐源性卒中的患者中,PFO封闭联合抗血小板治疗的患者中风复发率低于单独抗血小板治疗的患者。PFO封堵与房颤风险增加有关。(由法国卫生部资助; CLOSE ClinicalTrials.gov编号,NCT00562289。)
更新日期:2017-09-14
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