Annual Review of Virology ( IF 8.1 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-110615-042127 Ido Golding 1, 2, 3
Studies over more than half a century have resulted in what some consider a complete narrative for the life cycle of bacteriophage λ. However, this narrative is only complete within the limited resolution offered by the traditional genetic and biochemical approaches that were used to create it. A recent series of studies performed at the single-cell and single-phage levels has revealed a wealth of previously unknown features. By pointing to many open questions, these new studies highlight the limitations of our current understanding of λ, but they also initiate the process of forming a more detailed and quantitative narrative for the system.
中文翻译:
噬菌体λ的单细胞研究:Occam地毯下的隐藏宝藏
经过半个多世纪的研究,有人认为这是对噬菌体λ生命周期的完整叙述。但是,这种叙述仅在用于创建它的传统遗传和生物化学方法所提供的有限分辨率内是完整的。最近在单细胞和单噬菌体水平上进行的一系列研究揭示了许多以前未知的特征。通过指出许多悬而未决的问题,这些新研究突出了我们目前对λ的理解的局限性,但它们也启动了形成系统更详细,更定量的叙述的过程。