Annual Review of Virology ( IF 8.1 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-110615-042238 Balasubramanian Venkatakrishnan 1 , Adam Zlotnick 1
Hepatitis B virus is one of the smallest human pathogens, encoded by a 3,200-bp genome with only four open reading frames. Yet the virus shows a remarkable diversity in structural features, often with the same proteins adopting several conformations. In part, this is the parsimony of viruses, where a minimal number of proteins perform a wide variety of functions. However, a more important theme is that weak interactions between components as well as components with multiple conformations that have similar stabilities lead to a highly dynamic system. In hepatitis B virus, this is manifested as a virion where the envelope proteins have multiple structures, the envelope-capsid interaction is irregular, and the capsid is a dynamic compartment that actively participates in metabolism of the encapsidated genome and carries regulated signals for intracellular trafficking.
中文翻译:
乙型肝炎病毒的结构生物学:形式和功能
乙型肝炎病毒是人类最小的病原体之一,由3,200 bp的基因组编码,只有四个开放阅读框。然而,该病毒在结构特征上表现出了显着的多样性,通常相同的蛋白质具有几种构象。在某种程度上,这就是病毒的简约性,其中最少数量的蛋白质执行各种各样的功能。但是,一个更重要的主题是,组件之间以及具有相似稳定性的具有多个构象的组件之间的弱交互会导致系统高度动态化。在乙型肝炎病毒中,这表现为一种病毒颗粒,其中的包膜蛋白具有多种结构,包膜与衣壳的相互作用是不规则的,