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Melioidosis in lower provincial Cambodia: A case series from a prospective study of sepsis in Takeo Province
PLOS Neglected Tropical Diseases ( IF 3.4 ) Pub Date : 2017-09-13 , DOI: 10.1371/journal.pntd.0005923
Kevin L Schully 1 , Catherine M Berjohn 2 , Angela M Prouty 2 , Amitha Fitkariwala 2 , Tin Som 2 , Darith Sieng 2 , Michael J Gregory 1 , Andrew Vaughn 2 , Sim Kheng 3 , Vantha Te 4 , Christopher A Duplessis 1 , James V Lawler 1 , Danielle V Clark 1
Affiliation  

Melioidosis is a severe infectious disease caused by the gram-negative soil bacterium Burkholderia pseudomallei. Melioidosis is well known to be a major cause of morbidity and mortality in Southeast Asia, particularly in Thailand. However, melioidosis remains underreported in surrounding areas such as Cambodia. We report a case series of melioidosis in seven patients from Takeo Province, Cambodia. The patients, aged 24–65 years, were enrolled from May 2014 to May 2015 during a one year prospective study of sepsis at Takeo Provincial Hospital. They presented with fever, rigors, dyspnea, fatigue, diaphoresis, productive cough, and skin abscesses. Six of the seven patients were also hyponatremic. B. pseudomallei was cultured from the blood of six patients and the sputum of one patient. In this manuscript, we provide a detailed description of the clinical presentation, case management and laboratory confirmation of B. pseudomallei, as well as discuss the difficulties of identifying and treating melioidosis in low resource settings.



中文翻译:


柬埔寨下省的类鼻疽:武雄省脓毒症前瞻性研究的病例系列



类鼻疽是由革兰氏阴性土壤细菌类鼻疽伯克霍尔德氏菌引起的严重传染病。众所周知,类鼻疽是东南亚(尤其是泰国)发病和死亡的主要原因。然而,在柬埔寨等周边地区,类鼻疽的报告率仍然较低。我们报告了来自柬埔寨茶雄省的七名患者的类鼻疽病例系列。这些患者年龄在 24-65 岁之间,于 2014 年 5 月至 2015 年 5 月期间在武雄省立医院进行为期一年的脓毒症前瞻性研究。他们出现发烧、寒战、呼吸困难、疲劳、出汗、咳嗽和皮肤脓肿。七名患者中的六名也出现低钠血症。 B.从六名患者的血液和一名患者的痰中培养出假鼻疽。在这篇手稿中,我们详细描述了B 型病毒的临床表现、病例管理和实验室确认。假鼻疽,并讨论在资源匮乏的环境中识别和治疗类鼻疽的困难。

更新日期:2017-09-14
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