This study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy (¹³C NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5.27 nm. The entrapment of iron oxide nanoparticles in a dextran nanohydrogel matrix was confirmed by thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and Zeta potential data. The magnetic nanohydrogels presented superparamagnetic behavior and were colloidal stable in physiological during 30 days. Our findings suggest that the synthesized magnetic nanohydrogel are potential candidates for use in drug delivery systems due to its physicochemical and magnetic properties.

中文翻译：

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通过接枝到衍生化的葡聚糖上的聚丙烯酸的微乳液聚合获得的磁性纳米水凝胶

这项研究描述了通过细乳液聚合技术合成磁性纳米水凝胶。质子核磁共振波谱证实，右旋糖酐被甲基丙烯酸缩水甘油酯衍生化，将乙烯基锚定在多糖主链上，使其可用作微乳液聚合的大分子单体（¹³1 H NMR）。通过共沉淀合成磁铁矿纳米颗粒，然后空气氧化成磁铁矿。X射线衍射（XRD），拉曼光谱和透射电子显微镜（TEM）分析结果表明，获得了直径为5.27nm的磁赤铁矿纳米颗粒。通过热重分析（TGA），扫描透射电子显微镜（STEM）和Zeta电位数据确认了氧化铁纳米颗粒在葡聚糖纳米水凝胶基质中的截留。磁性纳米水凝胶表现出超顺磁性行为，并且在30天内的生理胶体稳定状态。我们的发现表明，合成的磁性纳米水凝胶由于其物理化学和磁性性质而成为在药物递送系统中使用的潜在候选者。