A series of inulin derivatives were synthesized in aqueous solution using acyl chlorides with varying alkyl chain length (C10-C16). They were characterised using a number of techniques including MALDI TOF-MS, ¹H NMR and FTIR and their degree of substitution determined. The solution properties of the hydrophobically modified inulins were investigated using dye solubilisation and surface tension and it was confirmed that the molecules aggregated in solution above a critical concentration (critical aggregation concentration, CAC). The value of the CAC was found to be reasonably consistent between the different techniques and was shown to decrease with increasing hydrophobe chain length. It was found that the C10, C12 and C14 derivatives formed stable oil-in-water emulsions and the emulsion droplet size decreased with increasing alkyl chain length. The C16 derivative was not able to produce stable oil-in-water emulsions; however, it was able to form stable water-in-oil emulsions. The fact that the derivatives are able to form micellar-like aggregates and stabilise emulsions makes them suitable candidates for the encapsulation and delivery of active compounds with potential application in food, cosmetic, personal care and pharmaceutical formulations.

中文翻译：

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长链脂肪酰氯疏水改性菊粉的合成，表征及理化性质

使用具有变化的烷基链长的酰氯（C10-C16），在水溶液中合成了一系列菊粉衍生物。使用多种技术对它们进行了表征，包括MALDI TOF-MS，¹1 H NMR和FTIR及其取代度确定。使用染料增溶作用和表面张力研究了疏水改性菊粉的溶液特性，并证实了分子在高于临界浓度（临界聚集浓度，CAC）的条件下在溶液中聚集。发现CAC的值在不同技术之间是合理一致的，并且随着疏水链长度的增加而降低。发现C10，C12和C14衍生物形成稳定的水包油乳液，并且乳液液滴的大小随烷基链长度的增加而减小。C16衍生物不能产生稳定的水包油乳状液；但是，它能够形成稳定的油包水型乳液。