This paper presents a model to predict acute dermal toxicity of plant protection products (PPPs) to terrestrial amphibian life stages from (regulatory) fish data. By combining existing concepts, including interspecies correlation estimation (ICE), allometric relations, lethal body burden (LBB) and bioconcentration modelling, an equation was derived that predicts the amphibian median lethal dermal dose (LD₅₀) from standard acute toxicity values (96-h LC₅₀) for fish and bioconcentration factors (BCF) in fish. Where possible, fish BCF values were corrected to 5% lipid, and to parent compound. Then, BCF values were adjusted to an exposure duration of 96 hours, in case steady state took longer to be achieved. The derived correlation equation is based on 32 LD₅₀ values from acute dermal toxicity experiments with 15 different species of anuran amphibians, comprising 15 different PPPs. The developed ICE model can be used in a screening approach to estimate the acute risk to amphibian terrestrial life stages from dermal exposures to PPPs with organic active substances. This has the potential to reduce unnecessary testing of vertebrates.

中文翻译：

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一种物种间相关模型，利用鱼的急性毒性和生物浓度数据预测植物保护产品对两栖动物陆地生命阶段的急性皮肤毒性

本文提出了一种模型，该模型可根据（监管）鱼类数据预测植物保护产品（PPP）对陆栖两栖动物生命阶段的急性皮肤毒性。通过结合现有的概念，包括种间相关性估计（ICE），异速关系，致死的身体负担（LBB）和生物浓度模型化，得出了一个方程，该方程可从标准急性毒性值（96-96）预测两栖动物的致死性真皮剂量中位数（LD ₅₀）。 h LC ₅₀）中的鱼类和鱼类中的生物浓缩因子（BCF）。在可能的情况下，将鱼的BCF值校正为5％脂质和母体化合物。然后，将BCF值调整为96小时的暴露持续时间，以防达到稳定状态所需的时间更长。导出的相关方程基于32 LD ₅₀15种不同的无环两栖动物（包括15种不同的PPP）在急性皮肤毒性实验中的应用价值。发达的ICE模型可用于筛查方法，以评估从皮肤接触有机活性物质到PPPs对两栖动物陆地生命阶段的急性风险。这有可能减少对脊椎动物的不必要的测试。